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The exon encoding the third outer loop of the protein (aa 214 through 268) which makes up a portion of the putative catalytic domain was removed by cre-mediated recombination. While shortened transcript was revealed by Northern blot analaysis of RNA obtained from homozygous mutant embryoid bodies, no protein was detected by Western blot analysis of primary cultured cells. Endogenous phosphatase activity was abolished in homozygous mutant embryoid bodies. (J:84753)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
