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The transgene includes the rabbit adult beta hemoglobin gene and a beta-2 pseudogene. in situ hybridization studies of metaphase spreads from the founder mouse chromosomes detected one transgene insertion site on Chromosome 1. Southern blot analyses of G1 mice estimated 20-40 copies of the transgene per cell. 3' S1 nuclease protection assays detected polyadenylated rabbit transcript in testis, but not in erythrocytes from G2 mice carrying the transgene.
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
