A neo cassette inserted by homologous recombination replaced the exon encoding subdomain XI which is essential for catalytic activity. Protein was undetected by Western blot analaysis of splenocytes obtained from homozygous mutant mice. (J:85266)
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A neo cassette inserted by homologous recombination replaced the exon encoding subdomain XI which is essential for catalytic activity. Protein was undetected by Western blot analaysis of splenocytes obtained from homozygous mutant mice. (J:85266)