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Exon 1, which encodes the initiator methionine and the first 27 amino acids, was replaced with a neo cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by either Western blot analysis of heart extracts or immunohistochemical staining of sections of the descending aorta and subcardinal vein. (J:84800)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
