Bacterial Cre recombinase cDNA was subcloned between a 3 kb fragment of the mouse Col2a1 promoter and its chondrocyte-specific enhancer region. Transgenic founders were generated by pronuclear injection. Confirmation that Cre was expressed as expected was accomplished by crossing transgenic mice with mice carrying the Rosa26 reporter gene (J:84273)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count