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The T(4Mllt3;9Mll)1Thr translocation was engineered to recapitulate the leukemia-associated human T(9;11)(p22;q23) translocation. The translocation was generated by interchromosomal cre mediated recombination of single loxP sites within Mlltm1Thr and Mllt3tm2Thr. Fusion transcript containing exon 8 of Mll and exon b of Mllt3 was identified in various tissues of mutant mice by RT-PCR analysis. (J:68500)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
