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A loxP flanked cassette containing neo and tk genes replaced a 257 bp fragment of intron 7, eliminating a portion of the internal promoter that drives expression of two short isoforms, TRdeltaalpha1 and TRdeltaalpha2. The floxed selection genes were excised prior to germline transmission. Whereas wild-type levels of transcript encoding the two longer isoforms, TRalpha1 and TRalpha2, were detected in homozygous mutant mice, the levels of transcript encoding the shorter isoforms were reduced. (J:84537)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
