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A 10kb segment including exons 7 and 8 (but not the splice acceptor site of exon 7) was replaced with lacZ coding sequence followed by a PGK-neomycin resistance gene. A fusion protein is produced which contains the N-terminal 242 amino acids of Runx1, including its nuclear localization sequences, combined with beta-galactosidase sequences. The fusion protein lacks Runx1 function. (J:56184)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
