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A 14.5 kb genomic fragment was replaced with an IRES-betageo-pA cassette that was expected to join the endogenous exon 2 splice acceptor site. The deleted region included exons 2 through 6, which encode 95% of the extracellular domain and all of the transmembrane domain. RT-PCR and Western blot analyses indicated the absence of transcript and protein in homozygous mutant mice. (J:84392)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
