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The 3 prime portion of exon 1 as well as a small part of intron 1 were replaced with DNA sequence encoding the N terminus of the bovine tau protein fused to the lacZ gene. mRNA for the targeted gene and its protein were undetectable in the brain of homozygous mice and were reduced in heterozygotes. (J:84116)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
