Tbxa2r^tm1Sna

Exon 2 and part of exon 3 were replaced with a neomycin resistance gene. This results in a deletion from the N terminus to the sixth transmembrane domain. Functional disruption of the gene was confirmed by loss of platelet aggregation in response to the thromboxane receptor agonist, I-BOP as well as by the absence of ligand binding activity in thymocytes. (J:84085)