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The coding region of the gene was replaced with a PGK-puromycin resistance cassette in WEC9.6 cells in which both Hist1h1c and Hist1he had already been modified. DNA from E7.5 embryos was examined PCR to confirm correct homologous recombination. Reverse phase HPLC of extracts from E10.5 embryos proved that no gene products were present. (J:83954)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
