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The transgene consists of a human PAH promoter and a sequence endcoding a truncated and activated from of human INSR. The mutant INSR contains the first 12 amino acids of the alpha subunit fused to 20% of the C-terminal portion of the alpha subunit and the entire beta subunit. Strong transgene expression in the liver (approximately 6.5-fold higher than endogenous mouse mRNA) was confirmed by RT-PCR and Western blot. Weak transgene expression was also observed in kidneys and testis. (J:80773)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
