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A cassette expressing the neomycin resistance gene and the thymidine kinase gene flanked by loxP sites was inserted into intron 2. An additional loxP site was placed in intron 3. Homologous recombination was confirmed by Southern blots. The insertion of a neoTK cassette into intron 2 of the Men1 locus (the T allele) disrupted the Men1 expression at RNA and protein levels, as shown by RT-PCR and Western blot, respectively. (J:83882)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
