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A PGK-Neo expression cassette was inserted in the "sense" orientation into exon 2. Homologous recombination was verified by Southern blot analysis. Two weak bands representing aberrent transcripts were seen in northern blots of mRNA from embryos homozygous from the targeted gene. RT-PCR analysis confirmed that none of these transcripts represented wild-type mRNA and affinity labelling of embryo fibroblasts with TGFbetaI indicated that there was no binding to TGFbetaRIII. (J:83727)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
