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EN
Several nucleotide substitutions, resulting in amino acid substitutions R37A, H38G, and R39S, were introduced to disrupt the nuclear localization signal and the dioxin-responsive element (DRE) binding domain in exon 2. Also, a neomycin resistance gene cassette was introduced into intron 1 for positive selection. Western blot analysis confirmed expression of the mutant protein is similar that of wild-type. (J:83597)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
