Gpx4^tm1Yana

All of the exons of the endogenous locus, encompassing the entire coding regions of the mitochondrial, non-mitochondrial, and sperm nuclei isoforms, were replaced with a neomycin selection cassette inserted by homologous recombination. Reduced levels of transcript and protein were observed in various tissues obtained from heterozygous mutant mice. (J:83472)