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A 2.3 kb genomic fragment encompassing the 5' DNase I hypersensitive site 3 (HS3) was replaced with a loxP site flanked neomycin resistance gene cassette inserted by homologous recombination. RT-PCR analysis indicated that the presence of neo cassette reduces Hbb expression by an additional 25 to 40% relative to Rr320tm1.1Ley. (J:33053)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
