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An 18 kb region between Igl-V1 and Igl-J1 was replaced with a pre-arranged VJ1 gene and a floxed ACN cassette containing a neo resistance gene and sperm-specific cre gene. The ACN cassette is excised in chimeric animals during spermatogenesis. Semiquantitative RT-PCR analysis confirmed the expression of the prearranged VJ1 insertion in splenic B cells. (J:83289)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
