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The coding region of exon 1 was replaced with lacZ. The floxed neo selection cassette was excised in vivo. Northern and Western blot analyses indicated an absence of normal transcript and protein in homozygous mutant mice. Expression of lacZ was driven by the endogenous promoter. (J:83166)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
