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The gene was disrupted by replacement of 165 bp of coding sequence with a lacZ-neo cassette via homologous recombination resulting in the fusion of the first 54 amino acids to the lacZ gene. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of RNA from the pituitary and eyes. (J:66737)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
