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A targeting vector containing a Dnmt1 cDNA fragment followed by a PGK-puro cassette was inserted upstream of the previously targeted coding region containing a neomycin selection cassette (Dnmt1tm1Enl) and downstream of the endogenous promoter. Northern blot analysis showed that transcript produced by the inserted cDNA sequence was at a level and size similar to that of the endogenous allele. (J:83179)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
