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A tyrosine to phenylalanine substitution was introduced at residue 516 (Y516F) of the Shc adaptor binding site and a floxed neo cassette was inserted into the upstream intron via homologous recombination. The neo cassette was removed by mating mutant animals to cre deleter line TgN(CMV-cre)1Cgn. (J:75365)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
