LoxP sites were introduced into exon 1 and intron 2. Transient expression of cre recombinase in correctly targeted ES cells facilicated the removal of the floxed region (part of exon 1 and entire exon 2). (J:82761)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count