Hbegf^tm1.1Mek

The loxP-flanked, wild-type Hbegf cDNA was excised from Hbegftm1Mek via Cre-mediated recombination in progeny of a cross between mice with the floxed allele and mice bearing a ubiquitously expressed cre transgene. The bacterial beta-galactosidase gene (lacZ) and the Pgk-neo cassette remain in place of most of exon 1 through exon 3 and most of the third intron of the native gene. Expression of lacZ is driven by the endogenous promoter; the beta-galactosidase protein is localized to the nucleus. (J:82728)