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A hypomorphic allele was generated by the replacement of exon 27 (coding nt 9418 through 9984) with an HPRT minigene. RT-PCR analysis identified a transcript lacking the targeted sequence encoding the RAD51-interacting domain. Truncated protein is translated and the ability of the protein to bind RAD51 is retained, putatively via the BRC motifs encoded by exon 11. The mutant protein contains more than 94% of the wild-type amino acid sequence. (J:49518, J:82434)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
