The 5' UTR was disrupted by the insertion of a floxed PGK-neo cassette into exon 1 by homologous recombination. Real-time quantitative PCR analsysis of homozygous mutant mice showed reduced levels of transcript ranging from 20% to 80% of wild-type levels, depending on the organ. (J:82257)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count