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To define the requirements of Prnp for conferring susceptibility to scrapie, N- terminal deletion mutants of the Prnp genes were constructed in transgenic mice. In this transgenic line, amino acids 32-80 were deleted but the codons for signal sequence and nine additional amino acids were retained to ensure correct processing and cellular localization. (J:32214)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
