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The transgene construct comprises the human APOA4 gene with ~7 kb of 5'- and 6 kb of 3'- flanking genomic DNA. This transgenic line was estimated by densitrometric Southern blot analysis to carry ~9 copies of the construct. Human APOA4 protein was detected in plasma of these mice at ~11 times the level in human plasma. Like the endogenous transcript, transgene-derived human Apoa4 mRNA was present at significant levels in liver and at much higher levels in intestine. (J:82359)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
