The entire coding region was replaced with a neomycin selection cassette inserted by homologous recombination. FACS analysis indicated an absence of the endogenous protein on the surface of platelets obtained from homozygous mutant mice. Western blot analysis of platelet lysates confirmed the lack of protein in homozogotes. (J:58516)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
Disruption caused by insertion of vector
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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