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Human APOA1 sequence carrying the milano missense mutation (R173C) which is associated with a reduced risk for cardiovascular disease was inserted into the endogenous locus via homologous recombination. Murine exons 2 through 3 were replaced with human exons 2 through 4, while murine exon 4 was disrupted by a neomycin selection cassette. (J:81908)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
