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The transgene consists of a modified cre recombinase gene fused to exon 1 of a human CD2 minigene just upstream of the translation initiation codon. The human CD2 promoter was used to drive transgene expression in T lymphocytes. The cre recombinase sequence was modified to include a nuclear localization signal and a modified KOZAK consensus sequence. Transgene expression was confirmed by immunohistochemical analysis of thymus and spleen from transgenic animals. (J:81648)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
