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A 769 bp fragment encompassing exon 2 and flanking intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The translational start codon was included in the deleted region. Transcript was undetected by Northern blot and RT-PCR analyses of various tissues obtained from homozygous mutant mice. The absence of protein was indicated by flow cytometric, Western blot, and immunostaining analyses. S100A and S100A8 proteins are not detected in peripheral leukocytes. (J:81642)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
