The insertion of a neomycin selection cassette deleted a portion of the zinc finger binding domain and precluded the translation of downstream amino acids. While normal transcript was undetected by Northern blot analysis of homozygous mutant brain and testis tissue, low levels of a transcript encoding 5' amino acids and a portion of neo was observed. (J:58099)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
Insertion, Intragenic deletion
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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