Erbb2^{tm3(Erbb2)Mul}

Exon 1 was replaced with a loxP-flanked rat Erbb2 cDNA followed by a neomycin selection cassette. Immunoprecipitation and western blot analysis demonstrated that a reduced level of expressed protein was present in muscle extracts derived from homozygous mice. Crossing mice carrying this allele with mice expressing Cre recombinase is expected to eliminate expression from this allele. (J:81565)