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A loxP-flanked neomycin selection cassette was inserted into intron 3 and a single loxP site was inserted into intron 5. Activity and protein mass assays on protein derived from kidney and liver of fasted homozygous mice demonstrated that this allele behaves as a hypomorph, retaining about 10-20% of normal activity. (J:63929)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
