Vamp1^lew

A spontaneous mutant identified at The Jackson Laboratory. A c.190G>T transversion creates a premature stop codon at glutamic acid codon 64 (p.E64*). The predicted protein that results would lack both a transmembrane domain and a calmodulin interaction domain. mRNA levels are severely reduced and no protein can be detected by immunohistochemistry in the brain. (J:148602)