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Two transgene constructs were used in the generation of this allele. One construct consists of a Tcra sequence encoding the Valpha2JalphaMT1-27 rearrangement, 6 kb of 5' flanking sequence, 3.8 kb of 3' flanking sequence, and a neomycin resistance gene. The other construct consists of a Tcrb sequence encoding the Vbeta8.3DJbeta2.4 rearrangement, 5.1 kb of 5' flanking sequence, 0.4 kb of 3' flanking sequence, and a neomycin resistance gene. This transgenic line carries multiple copies of both Tcra and Tcrb constructs cointegrated at one locus. (J:81330)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
