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The transgenic construct contained a bidirectional tTA/rtTA responsive promoter derived from the human cytomegalovirus promoter IE and flanked by sequence encoding luciferase and cre recombinase. Efficient cre mediated recombination, unaffected by position effect variegation, was demonstrated in hepatocytes. Transcription of in both directions was shown to be activated by rtTA in the presence of doxycycline. Transgene insertion is on chromosome 6C1 flanked by genes coding for the vomeronasal receptors V1rc14 and V1rc15 (K.Schonig, pers. commun.) (J:81196)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
