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The transgene consists of a 2.3 kb cDNA of a lymphoma-specific isoform (G1/p57) of RUNX2, and a human CD2 promoter. The human CD2 promoter was used to drive expression in T lymphocytes. Northern blot analysis of transgenic tissues revealed transgene expression in thymus, spleen, and mesenteric lymph node. Transgene expression was confirmed by Western blot analysis of thymocytes. (J:59021)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
