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A human genomic BCL2/IGH fusion minigene was used for the transgene. This construct represents a translocation mutation, t(14:18), found in human follicular B cell lymphomas, and includes 3 amino acid mutations found in human B cell lymphoma line SU-DHL-6. Because of the large size of BCL2 intron 2 (350 kb), a cDNA segment of the exon II/exon III junction was substituted. Transgene expression in the spleen and thymus was confirmed by S1 nuclease protection assay. (J:81147)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
