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The transgene consists of a mouse Cd4 promoter and a constitutively expressed flag-tagged human SKP1A sequence. Mouse Cd4 regulatory sequences were used to drive transgene expression in T lymphocytes. The Cd4 regulatory region includes the minimal enhancer, minimal promoter, 70 bp of exon 1, and part of intron 1. The Cd4 promoter lacks the silencer region and is transcriptionally active in both single- and double-positive T cells. Transgene expression was confirmed by Western blot analysis of thymocyte extracts from transgenic animals. (J:80320)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
