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Exon 2 of the endogenous locus was replaced with a cassette containing Beta-gal and neo genes, resulting in an isoform-specific mutation. Exon 2 is the second coding exon of the Citron-K isoform and is far upstream of the Citron-N trascriptional start site. Western blot analysis of cerebral, splenic, and thymic tissues inidicated an absence of the Citron-K isoform and showed normal levels of the Citron-N isoform in homozygous mutant mice. (J:77297)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
