Log In|Sign Up
EN
The entire Lta gene and the majority of the Tnf gene (to codon 113 in exon 4) were replaced by a neomycin selection cassette inserted by homologous recombination. No transcript or truncated protein was detected by a variety of assays including Northern blot analysis of concanavalin A stimulated splenocytes and ELISA of macrophage colony supernatants. Tnf activity was undetected in LPS stimulated homozygous mutant mice. (J:39519)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
