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The transgene consists of a beta-lactoglobulin promoter, active in mammary glands, and a fusion gene comprised of amino acids 1-750 of the sheep STAT5A gene, the terminal transactivation domain (amino acids 677-847) of human STAT6, and the kinase domain (amino acids 757-1129) of mouse Jak2. The resulting protein is a constitutively active STAT5a molecule with self-activating properties. Transgene expression was confirmed by Western blot and RT-PCR analysis of mammary glands from transgenic animals at day 6 of lactation. (J:80588)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
