Log In|Sign Up
EN
An inducible Mx1 promoter and a 762 bp DNA fragment containing the coding region of human IL11 was used for the transgene. The Mx1 promoter was included for transgene induction by interferon alpha/beta. Since the transgenic animals constitutively expressed human IL11, interferon induction was not implemented. The 3' untranslated region of the transgene contains exons, introns, and polyadenylation sequences from human GH. Transgene expression is constitutively active in several tissues examined by RT-PCR. Furthermore, Northern blot analysis detected transgene expression in the long bone of transgenic animals. (J:80706)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
