The entire human NOS3 genomic sequence and flanking regions was used for the transgene. Transgene expression was confirmed by Western blot analysis of aorta homogenates. Transgene expression was also observed by immunohistochemistry. Blood vessels and capillaries of heart sections from transgenic animals stained positive for human NOS3, as did sinusoids of the liver and kidney and capillaries of the glomeruli. (J:80701)