Tg(Thy1-cre/PGR*)1Gsc

This transgene expresses a fusion protein consisting of Cre recombinase and a modified ligand-binding domain of the human progesterone receptor under the control of a mouse Thy1 promoter. The ligand-binding domain was modified such that it binds and can be activated by the synthetic steroid, RU486, but not the endogenous ligand, progesterone. Upon induction of transgene expression with RU486, activity was noted in the hippocampus and cortex. The activity was also noted in small populations of cells in the inferior colliculus, the striatum, the thalamus, the brain stem, and the cerebellum. (J:69323, J:84610)