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A 4.9 kb genomic fragment containing exons 1 through 4 of the human APOE gene was adjoined to a 1.4 kb human PDGFB promoter fragment. Epsilon 2 (APOE2) was identified at both the mRNA and protein levels by RNase protection and Western blot analysis of transgenic brain tissue. Immunohistochemical analysis further localized the transgenic expression to hippocampal neurons. (J:78003)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
