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The transgene is composed of a human SFTPC promoter, a human mutant RAF1 cDNA, and an SV40 small T antigen intron and polyadenylation signal. The mutant RAF1 sequence is deleted for the N-terminus and is constitutively active and highly transforming. 3.7 kb of human SFTPC promoter sequences was used to drive transgene expression in lung epithelium. The transgene is highly expressed in lungs as observed by Western blot analysis. The transgene is also weakly expressed in kidneys. (J:80895)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
